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Avexa Shelves Development of HIV Drug Apricitabine AIDSmeds.com HIV/AIDS Treatment News

10.05.10

Avexa Limited has decided to end its development of apricitabine (ATC), a nucleoside reverse transcriptase inhibitor (NRTI), according to a May 10 announcement by the company. The decision was reached after an ATC Phase III study was closed and, according to Avexa, because of unsuccessful efforts to partner with other pharmaceutical companies to continue developing the drug.

Apricitabine was originally developed by BioChem Pharma (where it was called BCH10618), first sold to Shire Pharmaceuticals (where the drug was called SPD754) and then sold to Avexa. The NRTI’s chemical structure was similar to that of lamivudine (found in Epivir, Combivir and Trizivir) and emtricitabine (found in Emtriva, Truvada and Atripla), but with the advantage of being active against HIV resistant to lamivudine and emtricitabine.

The premature closing of ATC’s Phase III clinical trial was announced October 2, 2009. The company didn’t share the reason why it terminated the study before it completed the planned 48-week follow-up period. Avexa did, however, say that it planned to analyze the data and to explore partnership options with other pharmaceutical companies to potentially continue developing ATC.

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